A431 cells were subjected to SDS PAGE followed by western blot with FNab09783(EPCAM Antibody) at dilution of 1:2000
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab09783(EPCAM Antibody) at dilution of 1:500
Background
Epithelial cell adhesion molecule(EpCAM, CD326) is a type I transmembrane glycoprotein that functions as a homophilic, epithelial-specific intercellular cell-adhesion molecule. In addition to cell adhesion, EpCAM is also involved in cellular signaling, cell migration, proliferation, and differentiation. EpCAM is highly expressed on most carcinomas and therefore of potential use as a diagnostic and prognostic marker for a variety of carcinomas, and has become a therapeutic target.(PMID: 20837599; 19249674; 21576002; 22647938)